Evaluation of Anti-ulcer Effects of the Methanol Extract of Mangifera indica L Stem Bark

Aims: The anti-ulcer effects of methanol extract of Mangifera indica L stem bark was investigated on wistar rats.

Place and Duration of Study: The study was carried out between August and November 2013 in the Pharmacology Laboratory of Department of Pharmacology, Faculty of Basic Medical Sciences, University of Port Harcourt, Nigeria.

Methodology: The methanol extract of Mangifera indica was prepared. The doses of the extract administered to the rats were 100, 200 and 400 mg/kg p.o. respective, and cimetidine (100 mg/kg; p.o.) was the reference drug. Ulcer was induced with ethanol and indomethacin. Ulceration was assessed by the degree of ulceration, total ulcer scores and ulcer index of the various treatment groups.

Results: The extract showed a significant (p < 0.001), dose dependent inhibition of ulceration (reduction in ulcer index values) relative to control, in both the ethanol and indomethacin models.

Conclusion: This study therefore suggested that M. indica stem bark has ulcer-reducing properties.